Remote choline intake was inversely related to log-transformed WMHV (average change in log WMHV per 1-unit change in choline = −0.05 95% CI: −0.10, −0.01 P = 0.02). Results: Performance on the VM and VsM factors was better with higher concurrent choline intake in multivariable-adjusted models for VM (average change in neuropsychological factor per 1-unit change in choline = 0.60 95% CI: 0.29, 0.91 P < 0.01) and VsM (0.66 95% CI: 0.19, 1.13 P < 0.01). Four neuropsychological factors were constructed: verbal memory (VM), visual memory (VsM), verbal learning, and executive function. Participants underwent neuropsychological evaluation and brain MRI at exam 7. Objective: The objective was to determine whether a relation exists between dietary choline intake, cognitive function, and brain morphology in a large, nondemented community-based cohort.ĭesign: A dementia-free cohort of 1391 subjects (744 women, 647 men age range: 36–83 y mean ± SD age: 60.9 ± 9.29 y) from the Framingham Offspring population completed a food-frequency questionnaire administered from 1991 to 1995 (exam 5 remote intake) and from 1998 to 2001 (exam 7 concurrent intake). Brain atrophy and white-matter hyperintensity (WMH) are also associated with impaired cognitive function and AD.
Loss of cholinergic neurons is associated with impaired cognitive function, particularly memory loss and Alzheimer disease (AD). Background: Choline is the precursor to the neurotransmitter acetylcholine.
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